School of Natural Sciences

Faculty

Bio Image Jim Williams

Jim Williams

Adjunct Lecturer of Chemistry
Research Associate in Chemistry
Phone: (812) 941-2267
Office Location: PS 110A

Academic Background

Doctorate:
University of Louisville
Louisville, Kentucky
Degree: Doctorate
Major: Cancer Research
Masters:
Columbia University
New York
Degree: MBA
Major: Finance
Saint Louis University
St. Louis, Missouri
Degree: Master of Science
Major: Research
Bachelors:
Kent State University
Kent, Ohio
Degree: Bachelor of Science
Major: Chemistry
Minor: Biology

Biography

POSITIONS AND EMPLOYMENT

Indiana University Southeast
New Albany, IN
August 2011 to present
Visiting Assistant Professor of Chemistry

University of Louisville
Louisville, KY
September 2009 to July 2011
Visiting Professor of Chemistry

Indiana University Southeast
New Albany, IN
August 2005 to August 2009
Visiting Assistant Professor of Chemistry

American Synthetic Rubber Corp.
Louisville, KY
March 1991 to May 2005 (Retired)
Facility Training Manager
Quality Manager
Vice President R&D
ISO 14001 Project Leaders;
ISO 9001:2000 Project Leader & Technical Specialist

ChemMark Inc.
Cincinnati, OH
January 1990 to March 1991
Adhesive & Sealant Market Analyst

Protective Treatments Inc.
Dayton, OH
October 1986 to January 1990
Vice President of R&D

Borden Chemical Division
Louisville, KY
January 1982 to October 1986
Research Director for Adhesives & Chemical East

University of Louisville
Louisville, KY
August 1980 to January 1982
Adjunct Professor

First National Bank of Louisville
Louisville, KY January 1980 to January 1982
Vice President and Manager of Finance Analysis Department

Borden Chemical Division
Louisville, KY
July 1977 to January 1980
Vice President of R&D for Insulspray

Borden Chemical Division
Columbus, OH
October 1972 to July 1977
Capital Budget Analyst;
Manager of Financial Analysis;
Manager of Budgeting and Long Range Planning;
Manager of New Product Development and Market Analysis

PROFESSIONAL MEMBERSHIPS AND ACTIVITIES
 
American Chemical Society 1964 - present
American Society for Testing Materials (ASTM) 1997-1999
National Association of Accountants 1972-1975
National Association of Forest Products (1976-1981)
Boy Scouts of America Scoutmaster 1967 - 1974

EDUCATIONAL ACTIVITIES

Indiana University Southeast Courses

  • Elementary Chemistry (Nursing) C-102
  • Elementary Chemistry (Nursing) Laboratory C-122
  • Organic Chemistry 341
  • Organic Chemistry Laboratory C-343
  • Organic Chemistry Lecture C-342
  • Organic Chemistry Laboratory C-344
  • Undergraduate Research C-409
  • Physical Science & Society C-104
  • Introduction to Polymer Chemistry C-470

University of Louisville Courses

  • General Chemistry Laboratory C-103 (U of L)
  • Undergraduate Research C-391
  • General Chemistry C-201
  • Organic Chemistry 341
  • Organic Chemistry Laboratory C-343
  • Organic Chemistry Lecture C-342
  • Organic Chemistry Laboratory C-344

PATENTS

Patent No.United States Patent TitleDate Filed
4,225,680 Urea for Foam with Low Shrinkage 8/6/1979
4,343,718 Aqueous Foaming Agent Solution 4/17/1980
4,409,293 Wood Composites of Low Formaldehyde Emission 10/11/1983
4,501,851 Urea-Formaldehyde Precursor 2/28/1984
4,482,699 Low Emitting Aqueous Formulations of Aminoplast Resins and Process for Manufacturing Them 9/25/1983
4,410,685 Hydrolytically Stable Urea-Formaldehyde Resins and Process for Manufacturing Them 9/10/1982
4,530,713 Urea-Formaldehyde Suspension 7/25/1983
Brit. UK Pat GB 2040290 A 19800828

RESEARCH

Title: The Synthesis of the Potential anticancer compounds with amide and phosphine oxide functionalities.

The aim of this project is to develop an efficient synthetic route to the synthesis of new and novel compounds termed phosphine oxides. The unique chemical structure of this series of compounds, which contain an amide or nitrogen based carbocyclic or acyclic skeleton, and their potential for significant biological activity, make them a highly attractive target for this study.
Nitrogen-containing heterocycles such as indole (1) and barbituric acid (2) are being designed to show anticancer activity.1 Disubstituted pyridinyl phosphine oxides (3) and nitrosourea derivatives (4), for example, of tertiary phosphine oxide compounds also show novel anti-cancer activity.

The aim of this project is two-fold. First, the goal is to develop a novel synthetic methodology for this combined functionality and to synthesize new amide-phosphine or phosphonium oxide compounds for bioactivity testing.

During the synthesis of these compounds, the second goal is to teach students how to utilize the new Agilent 600 MHz Nuclear Magnetic Resonance (NMR) Spectrometer. The new equipment is used to identify the prepared products using the new phosphorus probe to identify the elemental phosphorous31  present in the desired products which heretofore has not been available previously.
Additionally, each semester’s research is conducted to fulfill several educational goals. First, the research is focused on developing, completing, and reporting on new synthetic pathways for the present reactions. This results in the student learning new laboratory techniques. For the undergraduate student researcher, the research teaches the fundamentals of literature searching and use of chemical drawing software along with the importance of keeping a laboratory notebook. This C-409 course  also offers an environment to improve the following additional skills:

  • Developing synthetic methods for organic compounds
  • Identifying organic compounds using collection of data
  • Processing research for purposes of:
    • Publication of scientific literature
    • Presentation at science-related conferences
  • Developing techniques of:
    • Synthesis
    • Recrystallization
  • Identifying organic compounds by using:
    • Fourier-Transform Infrared Spectroscopy
    • Nuclear Magnetic Resonance
    • Thin Layer Chromatography
    • High Performance Liquid Chromatography
  • Researching scientific literature by using:
    • SciFinder Scholar
    • U.S. Patents
  • Preparing literature and presentation materials for use at scientific conferences
  • Writing a short paper at the end of the semester that details the individual research effort
  1. Singh, Palwlinder; Kaaur, Matilnder; Verms, Pooje, Bioorganic & Medicinal Chemistry Letters, 2009, 19, 3054.
  2. Lam, Kim Hung; Gambari, Roberto; et. Al. , Bioorganic & Medicinal Chemistry Letters (2009), 19(8), 2266-2269.
  3. Gugova, R.; Vurbanov, S., Pharmazie; et. Al., (1991), 46(8), 603.

Professional Interests

Teaching
  • Teach students how to utilize the new Agilent 600 MHz Nuclear Magnetic Resonance (NMR) Spectrometer
Research
  • The Synthesis of the Potential anticancer compounds with amide and phosphine oxide functionalities.

Publications

Journal Articles
Curphey, Thomas J.; Amoelotti, Charles W.; Layloff, Thomas P.; McCartney, Roger l.; Williams, James Harold. "Electrochemical preparation of cyclopropanediol derivatives" JACS 91. 10. (1969). 2817-18.

VISITING SCIENTISTS

NATURAL SCIENCES CONTACT INFORMATION